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ea0007oc37 | Diabetes and metabolism | BES2004

Resistin as an acute phase reactant and a positive mediator of IL-6 and TNF-alpha secretion in isolated human subcutaneous adipocytes

Kusminski C , McTernan P , Fisher F , Valsamakis G , Chetty R , Harte A , Kumar S

Chronic sub-clinical inflammation is associated with both type 2 diabetes and related vascular complications which is coupled with pro-inflammatory markers, such as IL-6, TNF-alpha and C-reactive protein (CRP). Resistin is the latest protein to be linked with inflammation and insulin resistance in obesity. Adipose tissue has been previously established as a source of circulating resistin, TNF-alpha and IL-6. As our previous studies demonstrated a correlation between serum resi...

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ea0007p54 | Diabetes, metabolism and cardiovascular | BES2004

TLR mediated activation of the innate immune response in human adipocytes with associated down-regulation of adiponectin secretion and elevated TNF-alpha and IL-6 levels

Fisher F , Creely S , Burman C , Harte A , Chetty R , Valsamakis G , McTernan P , Kumar S

Type 2 diabetes (T2DM) is associated with insulin resistance and chronic sub-clinical inflammation. Pro-inflammatory cytokines produced from adipose tissue are secreted as part of the innate immune response and also associated with insulin resistance. In contrast, adipocyte derived adiponectin is associated with insulin sensitivity and also has anti-inflammatory properties. Hence fat may represent a site for mediating the innate immune response. We therefore investigated a mec...

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Endocrine Abstracts

Resistin as an acute phase reactant and a positive mediator of IL-6 and TNF-alpha secretion in isolated human subcutaneous adipocytes

TLR mediated activation of the innate immune response in human adipocytes with associated down-regulation of adiponectin secretion and elevated TNF-alpha and IL-6 levels

BiosciAbstracts